Job Title

Associate ScientistScientist, In vivo pharmacologyA well-funded and highly innovative start up from Third Rock Ventures is emerging out of stealth with a syndicate of marquee investors and is seeking a talented Associate ScientistScientist to join the Biology-In vivo pharmacology team. The Associate ScientistScientist will serve as the in vivo pharmacology representative for discovery-stage pipeline program(s) focused on antibody-driven diseases. The role will work collaboratively with the Biology team lead(s) to contribute to lead characterization and development candidate selection. The Associate ScientistScientist will aid in the management of external and internal in vivo pharmacology studies, including model development and characterization. The ideal candidate is an expert lab-based in vivo pharmacologist with a background in immunology and biologics drug discovery.Responsibilities:Serve as functional team lead for pre-clinical pipeline program(s) and work collaborativelypartner with peer team leads to advance program(s) to INDDesign and manage in vivo biology functional experiments that support preclinical drug discovery including PKPD analysis, mechanism of action studies, and disease modelingAssist in managing internal in vivo pharmacology capabilities at a shared vivarium space, including some animal handlingsample collectionIndependently develop and execute quantitative assays for the analysischaracterization of ex vivo samples (ELISA, flow cytometry)Manage out-sourced CRO-based workflows, including study design and data analysisRequired qualifications and experience: Ph.D. in relevant scientific area, such as immunology, cellmolecular biology with 0-3 years in BiotechPharma pharmacology group or BABS in a relevant scientific area with 8+ years experience in BiotechPharma industry within in vivo pharmacologyExtensive experience in the design and execution of in vivo studies, particularly in assessing pharmacokineticspharmacodynamics (biologics experience preferred)Experience in ex vivo sample analysis and data interpretation (immunophenotyping, ELISA)Capacity to work within a dynamic matrix environment, with strong contribution to project strategy and executionExcellent communication, presentation, and inter-personal skills; superb organizational and problem-solving skillsContribution to the design and execution of IND-enabling in vivo studies preferred