Organisation / Company: Queen Mary University of London Department: William Harvey Research Institute Laboratory: Biochemical Pharmacology Calls for Expressions of Interest European Fellowships The William Harvey Research Institute (WHRI) at Queen Mary University of London (QMUL) welcomes Expressions of Interest (EOI) from top talented postdoctoral researchers who demonstrate independence and an excellent research track record to apply with a QMUL host supervisor to the MSCA Postdoctoral Fellowships – call 2025. WHRI’s primary research focus and excellence lies in its cardiovascular, endocrine, and inflammation research and is home to international excellence in critical care and perioperative medicine research. WHRI aims to combine talents from different disciplines, such as genomics, cell biology, pharmacology with translational bench-to-patient studies and large-scale clinical trials all with the ambition of therapeutic innovation. WHRI comprises over 530 clinicians and scientists from 45 countries. What does the Fellowship entail? An MSCA European Postdoc Fellowshipcomprises a personalised, well-structured and feasible research project integrated with scientific and transferable skills training under the supervision of a well-matched WHRI PI supervisor (integrated into their research group) with optional secondment. It must show a ‘best fit’ of expertise with the PI supervisor and fellow that includes a two-way transfer of knowledge and experience as the candidate will be required to share skills and knowledge whilst hosted at QMUL and potential for further networking and collaboration as well as career development and mobility. Any age and nationality -your main activity (work/studies) must not have been in the UK for more than 12 months in the last 36 months prior to the EC MSCA PF call deadline of 10th September 2025 Holda PhD before the EC call deadline 10th September 2025 Have a maximum of eight years full-time research experience from the date of (first) PhD. Eligibility may be extended see MSCA Work (2023-2025) Programme for periods outside of research and career breakscertified by appropriate documents. Funding The EU provides support for the recruited researcher for 12 to 24 months to cover salary, a living allowance, a mobility allowance, research, training and networking activities, management and indirect costs - if applicable, family, long-term leave and special needs allowances. WHRI Research Areas/Topics: Biochemical Pharmacology: Drugging efferocytosis as a strategy for mitigating chronic inflammatory diseases Immunometabolic cross-talk in the inflamed diabetic heart Impact of diet and inflammation during pregnancy on maternal and fetal health Mapping pro-resolving receptors in hearts affected by inflammatory arthritis using Imaging Mass Cytometry to uncover mechanisms and identify novel drug targets Novel therapeutic strategies for clearance of neutrophil extracellular traps Regulation of inflammation resolution by clinically active South Africa medicinal plants: analytical and pharmacological characterisation Resolution Pharmacology: targeting cardiac metabolism to mitigate the cardiomyopathy of inflammatory arthritis The role of SGLT2 inhibitor in a novel “two-hit” model of cardiac diastolic dysfunction induced by arthritis and metabolic syndrome Therapeutic Potential of Modulating Myocardial ATP Homeostasis in Heart Failure (HFpEF and HFreF) Therapeutic Potential of Modulating Myocardial ATP Homeostasis in Type 2 Diabetes Uncovering Protective Mechanisms that Reprogram Immune Cells to Enhance Resilience and Limit Disease Cardiovascular Medicine and Devices: A novel proteomics approach to uncover biomarkers of coronary artery disease Cardiovascular Device Trials Coronary plaque characterisation Developing CLIC1 inhibitors for cardiovascular diseases Developing novel proteomics biomarker strategies for cardiovascular diseases Dissecting the mechanisms underlying sex differences in susceptibility to cardiovascular disease Do sex differences in inflammatory resolution drive differences in atherosclerosis development? Identify how mechanical forces shape junctional multiprotein complexes to modulate gene transcription, cell signalling and the physiological function of the endothelium Intracoronary imaging Investigating novel NO-delivery methods for preventing renal dysfunction Role of endothelial Neuropilin-1 in hypertension and heart failure The role of ABCB8 in regulating angiogenesis and arteriogenesis in ischemia Clinical Pharmacology & Precision Medicine: Comparing the safety and efficacy reported in the clinical trials data submitted for regulatory purposes with those collected in the real world: are there any disparities amongst less represented groups based on ethnicity, older age and biological sex? Deciphering gene-by-lifestyle interactions in multi-ancestry biobanks to modulate cardiovascular disease risk Defining biological mechanisms associated with severe mental illness Development of an application or algorithm for predicting drug response and blood pressure control in hypertensive patients within the community Disease mechanistic insights through the integration of ageing-related DNA methylome changes within ageing-related disease genomic loci Exploring the causal landscape of complex traits and diseases Exploring the clinical utility of novel AI-based Integrated Risk Score (IRS) for cardiovascular disease (CVD) Exploring the role of rare genetic variants with hypertension Genes essential for organism development – clinical and functional genetics Genetic Analyses to Identify Specific Drug Targets for AI-derived Sub-Phenotypes of Hypertension Harnessing redox signalling for therapeutic purposes Improving genetic diagnosis and discovery in rare diseases using family-based sequencing analytical tools Integrating multi-modal data with machine learning for enhanced coronary artery disease prediction in diverse populations Investigating the Pharmacogenetic Contribution to the Response to Statin Therapy Investigating the role of inflammation and immune system in psychotropic drug efficacy and safety Lifestyle determinants informing tailored behavioural interventions for cardiovascular disease prevention Multi-modal AI data integration for disease prediction Multi-modal data integration for thyroid disease and cancer early diagnosis Oxidant sensing and signalling Predicting stroke risk in patients with atrial fibrillation using machine learning approaches Role and efficacy of non-invasive neuromodulation in improving exercise capacity in individuals with heart failure with preserved ejection fraction and exploring various other non-pharmacological options Understanding how stress leads to disease Understanding relationships between electrocardiogram biomarkers with atrial fibrillation and ventricular arrhythmias Endocrinology: Adrenocortical stem cells in adrenal physiology and pathology Development of novel targeted therapies for adrenal cancer Genetic determinants of congenital hypopituitarism Genetics of adrenal insufficiency – finding new causal genes/mechanisms Identification of targeted therapies for HP-axis tumours Iron metabolism in the adrenal gland Obesity and multi-morbidities in Down syndrome Phenylalanine in the development of sarcopenia Phenylalanine in the development of HFpEF Role of cancer stem cells in paediatric hypothalamic pituitary tumours Role of melanocortin receptor accessory proteins in adrenal function and metabolism Role of neuroendocrine transcriptional regulation in disorders of human puberty The role of AIP in cardiac function The role of AIP in the brain Therapeutic potential of modulating phenylalanine levels in obstructive sleep apnoea-related cardiovascular complications Understanding the role of Wnt-driven cancer stem cells in hypothalamic-pituitary tumours Experimental Medicine and Rheumatology: Defining common and divergent biological mechanisms driving response/non-response to anti-rheumatic drugs in immune-mediated inflammatory diseases (IMIDs) Defining the neuroimmune basis of chemotherapy induced neuropathic pain Defining the neuroimmune basis of persistent pain in Multi-Drug Resistant Rheumatoid Arthritis Dissecting the contribution of Innate and Adaptive Immunity to non-resolving Synovial Inflammation in Multi-Drug Resistant Rheumatoid Arthritis Investigating the mechanistic basis of sex differences in osteoarthritis pain The biomechanical predictors of lower limb injury outcome – a cohort study within the highly phenotyped Biomedical Research Centre cohort Understanding neuro-musculo-skeletal system complexity in gait, and the impact of injury Microvascular Research: Autophagy as a means to control von Willebrand's factor secretion and blood clotting Identifying and targeting the mechanisms of neutrophil trafficking to lymphoid organs Targeting age-related metabolites to enhance hiPSC-cardiomyocyte differentiation Targeting endothelial-to-mesenchymal transition in chronic fibrotic diseases The role and mechanics of JAM-C trafficking in endothelial vascular function Understanding the interplay between neutrophils and lymphocytes in health and disease Understanding the roles of Atypical Chemokine Receptors in regulating endothelial cell identity in health and disease Translational Medicine and Therapeutics: Afferent neural regulation of autonomic pathways controlling acute inflammation Autonomic regulation of exerkine release in humans Mechanisms of myocardial injury after tissue injury The heart-brain axis: pathophysiology for vascular dementia The Immunopathology for Alzheimer's Disease, avenues for therapeutic interventions 1)CV and research achievements,including a full list of publications (max. two pages) 2)Two page outline of your research proposal(how your research is original, innovative, research outcomes and impacts and how it will advance your career). Also how you will contribute to WHRI’s research profile and topic. 3)Eligibility statementthat you meet the MSCA-2025-PF criteria (described above) withsupporting documentation(PhD certificate and completed MSCA extension eligibility tool (available on request via Agatha Ojugo). EOI results will be announced by Friday 13th June 2025. Selected candidates will then prepare the EC proposal with matched PI supervisor using EC guidance and templates supported by QMUL IRI EU pre-award who provide additional guidance materials and application technical support. QMUL was awarded nearly 70 Horizon 2020 individual fellowships and ranked 9th in the UK and 18th in Europe for H2020 fellowships and hosts over 20 successfully evaluated Horizon Europe fellowships. EC Funding Deadline The EC MSCA-PF (2025) call opens 8 May with deadline of 10 September 2025.#J-18808-Ljbffr
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